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Development of an endothelial cell restricted transgenic reporter rat: A resource for physiological studies of vascular biology
Date
2020-06-26
Authors
Alexeyev, Mikhail
Geurts, Aron M.
Annamdevula, Naga S.
C. Michael Francis
Silas Leavesley
Thomas Rich
Mark S. Taylor
Mike Lin
Ron Balczon
Jennifer Knighten
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Transgenic mice have been instrumental in advancing molecular insight of physiological processes, yet these models oftentimes do not faithfully recapitulate human physiology and pathophysiology. Rat models better replicate some human conditions, like Group 1 pulmonary arterial hypertension. Here, we report the development of an endothelial cell restricted transgenic reporter rat that has broad application to vascular biology. This first-in-kind model offers exceptional endothelial restricted tdTomato expression, in both conduit vessels and the microcirculations of organs.
Description
Article originally published in American Journal of Physiology- Heart and Circulatory Physiology - doi.org/10.1152/ajpheart.00276.2020.
Keywords
CDH5 (VE-cadherin), Cre recombinase (iCre), td Tomato, Animal model