DEVELOPING METHODS FOR INVESTIGATING DIMETHYL TRISULFIDE IN AQUEOUS SOLUTIONS

Date

2023-08-01T05:00:00.000Z

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Abstract

Dimethyl trisulfide (DMTS) is currently being investigated as an antidotal candidate for cyanide poisoning. DMTS is lost from aqueous solution more rapidly than would be expected given that its boiling point exceeds that of water. Prior investigations have shown that the preferential loss of DMTS from aqueous solutions is reproducible but have not yet provided a scientific explanation for the loss. To lay a foundation for addressing this question, an accelerated evaporation apparatus was assembled that allowed sampling at regular time intervals from an evaporation flask and an attached cold trap. The decrease of DMTS concentrations in these samples was then followed by NMR and HPLC characterization, taking into consideration the susceptibility of DMTS to photolysis and thermolysis induced disproportionation. The rate of DMTS loss in this accelerated evaporation model system greatly exceeds natural rates of disproportionation, strongly suggesting that, under the conditions of accelerated evaporation, the preferential losses of DMTS are due primarily to direct preferential evaporation of DMTS, and with only very small contributions from the evaporation of disproportionation products. Under slower rates of evaporation, the indirect loss of DMTS via disproportionation pathways is expected to be more significant.

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Chemistry, Analytical

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