Development of an endothelial cell restricted transgenic reporter rat: A resource for physiological studies of vascular biology

Simple item page
dc.contributor.authorAlexeyev, Mikhail
dc.contributor.authorGeurts, Aron M.
dc.contributor.authorAnnamdevula, Naga S.
dc.contributor.authorC. Michael Francis
dc.contributor.authorSilas Leavesley
dc.contributor.authorThomas Rich
dc.contributor.authorMark S. Taylor
dc.contributor.authorMike Lin
dc.contributor.authorRon Balczon
dc.contributor.authorJennifer Knighten
dc.contributor.authorDiego F. Alvarez
dc.contributor.authorTroy Stevens
dc.date.accessioned2020-07-08T21:08:07Z
dc.date.available2020-07-08T21:08:07Z
dc.date.issued2020-06-26
dc.descriptionArticle originally published in American Journal of Physiology- Heart and Circulatory Physiology - doi.org/10.1152/ajpheart.00276.2020.
dc.description.abstractTransgenic mice have been instrumental in advancing molecular insight of physiological processes, yet these models oftentimes do not faithfully recapitulate human physiology and pathophysiology. Rat models better replicate some human conditions, like Group 1 pulmonary arterial hypertension. Here, we report the development of an endothelial cell restricted transgenic reporter rat that has broad application to vascular biology. This first-in-kind model offers exceptional endothelial restricted tdTomato expression, in both conduit vessels and the microcirculations of organs.
dc.description.departmentOsteopathic Medicine
dc.identifier.urihttps://hdl.handle.net/20.500.11875/2814
dc.subjectCDH5 (VE-cadherin)
dc.subjectCre recombinase (iCre)
dc.subjecttd Tomato
dc.subjectAnimal model
dc.titleDevelopment of an endothelial cell restricted transgenic reporter rat: A resource for physiological studies of vascular biologyen_US
dc.typeArticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Alexeyev-AJPH-2020-endothelial transgenic rat.pdf
Size:
2.94 MB
Format:
Adobe Portable Document Format
Description:
Article
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.63 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

College of Osteopathic Medicine