Individual differences in the impact of stress on alcohol use, binge drinking, and alcohol use onset: The role of developmental and biological variation

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dc.contributor.advisorBoisvert, Danielle
dc.contributor.committeeMemberBouffard, Leana
dc.contributor.committeeMemberFranklin, Cortney
dc.creatorWells, Jessica
dc.date.accessioned2017-05-02T14:02:10Z
dc.date.available2017-05-02T14:02:10Z
dc.date.created2017-05
dc.date.issued2017-04-19
dc.date.submittedMay 2017
dc.date.updated2017-05-02T14:04:17Z
dc.description.abstractPrevious research suggests that both distal and proximal environmental stressors impact later alcohol use behaviors. Introduction of the stress sensitization hypothesis has highlighted that the effects of these environmental stressors may not be limited to direct effects but, rather, are interactive wherein the impact of proximal life stress are greater for individuals who have experienced distal stress such as childhood abuse (ExE). At the same time, gene-environment (GxE) interaction studies have examined how the effects of both distal and environmental stress is moderated by genetic polymorphisms in two-way interactions. The current study seeks to add to a small body of literature seeking to merge these two processes by examining a genetically moderated stress sensitization hypothesis (GxExE) on alcohol use, binge drinking, and alcohol use onset. The current dissertation further contributes to this body of literature by assessing gender-specific GxExE effects and presenting preliminary models gender-specific alcohol dependence and the role of sex-role identification in alcohol use, binge drinking, and alcohol use onset. Mixed results concerning the serotonergic polymorphisms, MAOA and 5-HTTLPR, two-way and three-way interactions with distal and proximal environmental stress were found. These findings and implications for programming designed to reduce alcohol use are discussed.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/20.500.11875/2214
dc.language.isoen
dc.subjectChildhood abuse
dc.subjectStress
dc.subjectStress sensitization
dc.subjectMAOA
dc.subject5-HTTLPR
dc.subjectAlcohol use
dc.subjectBinge drinking
dc.subjectAlcohol use onset
dc.titleIndividual differences in the impact of stress on alcohol use, binge drinking, and alcohol use onset: The role of developmental and biological variation
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentCriminal Justice and Criminology
thesis.degree.grantorSam Houston State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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